The Mutographs Project, part of Cancer Research UK’s ‘Grand Challenge’, is an international project led by Professor Mike Stratton at the Wellcome Sanger Institute. Involving geneticists, chemists, bioinformaticians, epidemiologists and patient advocates, it aims to explain major global differences in cancer incidence through the analysis of cancer samples from 5,000 patients, covering 5 different types of cancer, and across 5 continents.
It has long been known that certain human behaviours, such as smoking or drinking alcohol, or exposure to environmental factors such as UV light, can cause damage to the DNA within cells. This damage occurs in distinctive patterns, known as Mutational Signatures, which are unique to the factor that caused the damage. The Mutational Signatures component of the Mutographs Project aims to discover some of the unknown factors that cause cancer, using computational approaches to the analysis of mutational signatures.
An opportunity exists to join the mutational signatures project. The successful applicant will be embedded within COSMIC, (the Catalogue Of Somatic Mutations In Cancer,) at the Wellcome Sanger Institute, and will work closely with Mutographs team member Ludmil Alexandrov, at the University of California, San Diego, to build web-based tools for the visualisation and analysis of known mutational signatures. The application will integrate the analysis pipeline provided by the Alexandrov team, allowing external researchers to analyse their own data using the computational resources of the Sanger Institute. As a member of the COSMIC web team, in addition to building tools for mutational signatures analysis you will also have the opportunity to contribute to the development of COSMIC’s new internal curation platform and our new externally-facing web portal.
We’re looking for a developer with practical experience of building modern web applications, especially using platforms such as Python/Django or front-end frameworks such as ReactJS. We’re particularly keen to hear from you if you have experience of data visualisation or data science. Previous experience of working with cancer, biological, or other scientific data would also be advantageous but is not necessary.
Our technology stack includes:
If you’ve worked with some or all of these technologies we would love to hear from you. These are some of the other skills and abilities that would be useful:
You don’t need to have all of these skills because you’ll be joining a team with experience that will complement your own. However, it is important that you have a passion for writing clear, concise and well-tested code, as well as good team working and communication skills. You’ll be working with a team that includes remote workers and collaborators in different geographical locations and time zones, and you’ll need to be able to work well with such a distributed team.
As a signatory to the Technician Commitment, the Wellcome Sanger Institute is committed to valuing, developing and rewarding our highly skilled technical employees.
For informal queries, please contact Laura Humphreys – firstname.lastname@example.org
Closing Date: 25th March 2020
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